Haemophilia A

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Haemophilia A
Synonyms	Classical haemophilia, factor VIII deficiency
Pronounce
Specialty	Hematology
Symptoms	Prolonged bleeding, easy bruising, joint pain
Complications	Hemarthrosis, intracranial hemorrhage, anemia
Onset	Childhood
Duration	Lifelong
Types
Causes	Genetic mutation in the F8 gene
Risks	Family history
Diagnosis	Blood test for factor VIII activity
Differential diagnosis	Von Willebrand disease, Hemophilia B
Prevention
Treatment	Factor VIII replacement therapy, desmopressin
Medication
Prognosis	Variable, depends on severity and treatment
Frequency	1 in 5,000 male births
Deaths

Haemophilia A

Haemophilia A

Haemophilia A

Haemophilia A

Haemophilia A

Haemophilia A

Haemophilia A is a genetic disorder that affects the body's ability to clot blood. It is caused by a deficiency in factor VIII, a protein that is necessary for blood clotting. This condition is typically inherited and affects males more often than females.

Symptoms

The primary symptom of Haemophilia A is prolonged bleeding. This can occur after an injury or surgery, and in severe cases, spontaneous bleeding can occur. Other symptoms can include:

• Bleeding into joints and muscles
• Blood in urine or stool
• Nosebleeds
• Bruising
• Bleeding gums

Causes

Haemophilia A is caused by a mutation in the F8 gene, which provides instructions for making factor VIII. This mutation can be inherited from a parent, or it can occur spontaneously.

Diagnosis

Diagnosis of Haemophilia A typically involves blood tests to measure the level of factor VIII in the blood. Genetic testing may also be used to identify the specific mutation causing the condition.

Treatment

Treatment for Haemophilia A typically involves replacing the missing factor VIII through infusions. Other treatments can include:

• Antifibrinolytic medicines
• Physical therapy
• Pain medicines

See Also

• Haemophilia B
• Von Willebrand disease
• Factor V Leiden