Hydroxyurea dermopathy
Hydroxyurea dermopathy is a skin condition caused by chronic use of hydroxyurea for various indications such as chronic myelogenous leukemia, thrombocytosis, or psoriasis, and presents with skin lesions characteristic of dermatomyositis.[1]
Cause[edit | edit source]
Chronic treatment with the drug hydroxyurea
Symptoms[edit | edit source]
Symptoms of hydroxyurea dermopathy include: Lichenoid papules, telangiectasia, and poikilodermatous lesions on the dorsal hands and digits[2].
Histology[edit | edit source]
Interface dermatitis, focal lichenoid reaction with epidermal atrophy, and Civatte bodies were the most common histologic findings. Endothelial swelling also was noted.
Immunology[edit | edit source]
Cytoid staining with multiple conjugates was the most common immunopathologic finding.
Diagnosis[edit | edit source]
Clinical history, and biopsy with histology and immunologic testing as noted above.
Treatment[edit | edit source]
Most patients show significant improvement after discontinuation of hydroxyurea.
See also[edit | edit source]
ICD[edit | edit source]
ICD10 code: Y43.3 ICD9 code:E933.1
References[edit | edit source]
- ↑ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders.
- ↑ Daoud MS, Gibson LE, Pittelkow MR. Hydroxyurea dermopathy: a unique lichenoid eruption complicating long-term therapy with hydroxyurea. J Am Acad Dermatol. 1997 Feb;36(2 Pt 1):178-82. doi: 10.1016/s0190-9622(97)70276-7. PMID: 9039164.
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Contributors: Prab R. Tumpati, MD
