IgG4-related ophthalmic disease
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| IgG4-related ophthalmic disease | |
|---|---|
| Synonyms | IgG4-ROD |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Proptosis, diplopia, vision loss, periorbital swelling |
| Complications | Optic neuropathy, vision impairment |
| Onset | Middle-aged to elderly adults |
| Duration | Chronic |
| Types | N/A |
| Causes | IgG4-related disease |
| Risks | Unknown |
| Diagnosis | Clinical examination, imaging studies, biopsy |
| Differential diagnosis | Thyroid eye disease, orbital cellulitis, lymphoma |
| Prevention | N/A |
| Treatment | Corticosteroids, immunosuppressive therapy |
| Medication | Prednisone, rituximab |
| Prognosis | Variable, can lead to permanent vision loss if untreated |
| Frequency | Rare |
| Deaths | N/A |
IgG4-related ophthalmic disease is a type of IgG4-related disease that affects the eyes and surrounding tissues. It is characterized by the infiltration of IgG4-positive plasma cells and lymphocytes into various organs, including the eye, lacrimal gland, and orbit. This disease can cause a variety of symptoms, including eye pain, swelling, and vision loss.
Symptoms[edit | edit source]
The symptoms of IgG4-related ophthalmic disease can vary widely, depending on the specific tissues affected. Common symptoms include:
- Eye pain
- Swelling around the eyes
- Vision loss
- Double vision
- Dry eyes
- Red eyes
Causes[edit | edit source]
The exact cause of IgG4-related ophthalmic disease is unknown. However, it is thought to be an autoimmune disease, in which the body's immune system mistakenly attacks its own tissues.
Diagnosis[edit | edit source]
Diagnosis of IgG4-related ophthalmic disease is often challenging due to its nonspecific symptoms and overlap with other diseases. It typically involves a combination of clinical evaluation, imaging studies, and tissue biopsy.
Treatment[edit | edit source]
Treatment for IgG4-related ophthalmic disease typically involves corticosteroids to reduce inflammation and suppress the immune response. In severe cases, other immunosuppressive drugs may be used.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
