Irvine–Gass syndrome
Irvine–Gass syndrome
Irvine–Gass syndrome, also known as pseudophakic cystoid macular edema (PCME), is a condition characterized by the accumulation of fluid in the macula, leading to swelling and impaired vision. This syndrome typically occurs after cataract surgery and is one of the most common causes of decreased vision following the procedure.
Pathophysiology[edit | edit source]
The exact mechanism of Irvine–Gass syndrome is not fully understood, but it is believed to involve inflammation and the breakdown of the blood-retinal barrier. This leads to the leakage of fluid into the macula, resulting in cystoid macular edema. Inflammatory mediators such as prostaglandins and cytokines are thought to play a significant role in this process.
Symptoms[edit | edit source]
Patients with Irvine–Gass syndrome may experience:
- Blurred or decreased central vision
- Distorted vision (metamorphopsia)
- Difficulty reading or recognizing faces
Diagnosis[edit | edit source]
Diagnosis of Irvine–Gass syndrome is typically made through clinical examination and imaging studies. Key diagnostic tools include:
Treatment[edit | edit source]
Treatment options for Irvine–Gass syndrome may include:
- Topical nonsteroidal anti-inflammatory drugs (NSAIDs)
- Topical corticosteroids
- Intravitreal injections of corticosteroids or anti-VEGF agents
Prognosis[edit | edit source]
The prognosis for patients with Irvine–Gass syndrome is generally good, especially with early diagnosis and appropriate treatment. Most patients experience significant improvement in vision with treatment, although some may have persistent visual impairment.
Prevention[edit | edit source]
Preventive measures may include the use of prophylactic NSAIDs or corticosteroids in patients undergoing cataract surgery, particularly those at higher risk for developing Irvine–Gass syndrome.
Related Pages[edit | edit source]
- Cataract surgery
- Macular edema
- Optical coherence tomography
- Fluorescein angiography
- Nonsteroidal anti-inflammatory drug
- Corticosteroid
Categories[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD