KT 5720

KT 5720 is a potent and selective inhibitor of protein kinase A (PKA), a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). KT 5720 is often used in cellular biology to inhibit PKA and thus prevent the phosphorylation of key proteins involved in various cellular processes.

Structure and Function

KT 5720 is a derivative of the fungal metabolite K-252a, and it inhibits PKA by binding to the catalytic subunit of the enzyme. This binding prevents the enzyme from interacting with its substrates, thereby inhibiting its activity. The inhibition of PKA by KT 5720 is reversible and competitive with respect to ATP.

Applications in Research

KT 5720 has been widely used in research to study the role of PKA in various cellular processes. For example, it has been used to investigate the role of PKA in the regulation of glucose metabolism, gene expression, and cell proliferation. In addition, KT 5720 has been used to study the effects of PKA inhibition on the activity of other signaling pathways, such as the MAPK/ERK pathway and the PI3K/Akt pathway.

Potential Therapeutic Applications

Given the central role of PKA in many cellular processes, there is interest in the potential therapeutic applications of PKA inhibitors like KT 5720. For example, PKA inhibitors may have potential in the treatment of cancer, diabetes, and cardiovascular disease. However, further research is needed to fully understand the therapeutic potential of these compounds.

See Also

• Protein kinase A
• K-252a
• Cyclic AMP

References

‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian