Kanamycin A

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Kanamycin A

Kanamycin A is an aminoglycoside antibiotic that is used to treat a wide variety of bacterial infections. It is derived from the bacterium Streptomyces kanamyceticus. Kanamycin A is particularly effective against Gram-negative bacteria, but it also has activity against some Gram-positive bacteria.

Mechanism of Action[edit | edit source]

Kanamycin A works by binding to the 30S ribosomal subunit of bacterial ribosomes. This binding interferes with the process of protein synthesis by causing misreading of mRNA and inhibiting translocation. As a result, the bacteria are unable to produce essential proteins, leading to their death.

Clinical Uses[edit | edit source]

Kanamycin A is used to treat a variety of infections, including:

Administration and Dosage[edit | edit source]

Kanamycin A is typically administered via intramuscular injection or intravenous infusion. The dosage and duration of treatment depend on the type and severity of the infection, as well as the patient's age, weight, and kidney function.

Side Effects[edit | edit source]

Common side effects of Kanamycin A include:

Resistance[edit | edit source]

Bacterial resistance to Kanamycin A can occur through various mechanisms, including:

  • Enzymatic modification of the antibiotic
  • Alteration of the target site
  • Efflux pumps that expel the antibiotic from the bacterial cell

Related Antibiotics[edit | edit source]

Kanamycin A is part of the aminoglycoside class of antibiotics, which also includes:

See Also[edit | edit source]

References[edit | edit source]

External Links[edit | edit source]


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