LEFTY2

LEFTY2 is a gene that in humans is encoded by the LEFTY2 (Left-Right Determination Factor 2) gene. It is a member of the transforming growth factor beta (TGF-beta) family of proteins. These proteins are involved in different cellular processes, including cell growth, cell differentiation, apoptosis, and immune response.

Function

LEFTY2 is a secreted protein that is expressed in the decidua and embryonic trophectoderm of the preimplantation embryo. It plays a critical role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding.

Clinical significance

Mutations in the LEFTY2 gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some of these malformations include transposition of the great arteries, double outlet right ventricle, and persistent truncus arteriosus.

Research

Research on the LEFTY2 gene is ongoing, with studies focusing on its role in development and disease. It is also being studied for its potential use in gene therapy and other medical applications.

See also

• Transforming growth factor beta
• Gene therapy
• Asymmetry