LY-307,452
LY-307,452 is a drug used in neuroscience research, which was among the first compounds found that acts as a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3),[1] and was useful in early studies of this receptor family,[2][3] although it has largely been replaced by newer drugs such as LY-341,495.
References[edit | edit source]
- ↑ Wermuth CG, Mann A, Schoenfelder A, Wright RA, Johnson BG, Burnett JP, Mayne NG, Schoepp DD, (2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase, Journal of Medicinal Chemistry, Vol. 39(Issue: 4), pp. 814–6, DOI: 10.1021/jm9508144, PMID: 8632404,
- ↑ Li XC, Beart PM, Monn JA, Jones NM, Widdop RE, Type I and II metabotropic glutamate receptor agonists and antagonists evoke cardiovascular effects after intrathecal administration in conscious rats, British Journal of Pharmacology, Vol. 128(Issue: 3), pp. 823–9, DOI: 10.1038/sj.bjp.0702850, PMID: 10516668, PMC: 1571690,
- ↑ Sung KW, Choi S, Lovinger DM, Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses, Journal of Neurophysiology, Vol. 86(Issue: 5), pp. 2405–12, PMID: 11698530,
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