LY-88329
LY-88329 is a pharmacological agent that belongs to the class of serotonin and norepinephrine reuptake inhibitors (SNRIs). It is primarily used in the treatment of major depressive disorder (MDD) and generalized anxiety disorder (GAD).
Pharmacology[edit | edit source]
LY-88329 works by inhibiting the reuptake of serotonin and norepinephrine, two neurotransmitters in the brain. This increases the levels of these neurotransmitters in the synaptic cleft, which can help to alleviate the symptoms of MDD and GAD.
Clinical Use[edit | edit source]
LY-88329 is used in the treatment of MDD and GAD. It may also be used off-label for other conditions, such as panic disorder and social anxiety disorder.
Side Effects[edit | edit source]
Common side effects of LY-88329 include nausea, dry mouth, dizziness, and sleep disturbances. In rare cases, it can cause more serious side effects, such as serotonin syndrome or suicidal ideation.
Contraindications[edit | edit source]
LY-88329 is contraindicated in individuals with a known hypersensitivity to the drug. It should also be used with caution in individuals with a history of bipolar disorder, as it can trigger a manic episode.
See Also[edit | edit source]
- Serotonin and norepinephrine reuptake inhibitors
- Major depressive disorder
- Generalized anxiety disorder
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Contributors: Prab R. Tumpati, MD
