Lisch

Lisch nodules are hamartomas of the iris and are named after the ophthalmologist Karl Lisch, who first described them in 1937. They are small, well-defined, dome-shaped nodules that are usually brown or tan in color. Lisch nodules are a common feature of Neurofibromatosis type 1 (NF1), a genetic disorder characterized by the growth of non-cancerous tumors along the nerves of the skin, brain, and other parts of the body.

Clinical significance

Lisch nodules are harmless and do not affect vision. However, their presence can be a useful diagnostic indicator for Neurofibromatosis type 1 (NF1). They are one of the diagnostic criteria for NF1, along with café-au-lait spots, freckling in the armpit or groin, optic glioma, two or more neurofibromas, a distinctive bone lesion, and a first-degree relative with NF1.

Diagnosis

Lisch nodules can be detected during a routine eye examination. They are usually visible on the surface of the iris, but can also be found on the eyelid or conjunctiva. The nodules are typically multiple and bilateral, and increase in number and size with age.

Treatment

No treatment is necessary for Lisch nodules as they do not affect vision or cause any discomfort. However, regular eye examinations are recommended for individuals with NF1 to monitor for other potential eye problems.

See also

• Neurofibromatosis
• Hamartoma
• Iris (anatomy)

Lisch Resources
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