Loeffler's syndrome

Loeffler's Syndrome is a rare, transient pulmonary condition characterized by the presence of eosinophils, a type of white blood cell, in the lung. The syndrome is named after Wilhelm Loeffler, a Swiss physician who first described the condition in 1932.

Etiology

The exact cause of Loeffler's Syndrome is unknown. However, it is often associated with parasitic infections, such as ascariasis and strongyloidiasis, and allergic reactions to certain drugs or substances.

Symptoms

Symptoms of Loeffler's Syndrome include cough, shortness of breath, and wheezing. Some patients may also experience fever, weight loss, and general malaise. In severe cases, the condition can lead to pulmonary fibrosis, a serious lung disease that results in scarring of the lungs.

Diagnosis

Diagnosis of Loeffler's Syndrome is based on clinical symptoms and a high eosinophil count in the blood or lung tissue. Imaging tests, such as a chest X-ray or computed tomography (CT) scan, may show abnormalities in the lungs. A lung biopsy may be performed to confirm the diagnosis.

Treatment

Treatment for Loeffler's Syndrome primarily involves managing the symptoms and treating the underlying cause, if identified. This may include antiparasitic drugs for parasitic infections or corticosteroids to reduce inflammation in the lungs. In most cases, the condition resolves on its own within a few weeks to months.

Prognosis

The prognosis for Loeffler's Syndrome is generally good, with most patients making a full recovery. However, in rare cases, the condition can lead to serious complications, such as pulmonary fibrosis or cardiomyopathy, a disease of the heart muscle.

See Also

• Eosinophilia
• Pulmonary Eosinophilia
• Hypereosinophilic Syndrome

NIH genetic and rare disease info

• NIH info on Loeffler's syndrome

Loeffler's syndrome is a rare disease.

Loeffler's syndrome Resources
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