Loxoprofen

Loxoprofen is a nonsteroidal anti-inflammatory drug (NSAID) in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. It is available over-the-counter in Japan and Brazil.

Pharmacology

Loxoprofen is a prodrug with little to no anti-inflammatory effects until it is converted to its active form in the body. This active metabolite inhibits the synthesis of prostaglandins by inhibiting cyclooxygenase (COX), an enzyme that is involved in inflammation and pain.

Medical uses

Loxoprofen is used to treat pain and inflammation from a variety of conditions including rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is also used for pain relief in non-articular rheumatism, postoperative pain, and primary dysmenorrhea.

Side effects

Like other NSAIDs, side effects can include gastrointestinal bleeding, peptic ulcer, and renal impairment. Other side effects can include rash, dizziness, and changes in blood counts.

See also

• List of NSAIDs
• Pain management

Loxoprofen Resources
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