Lung cancer susceptibility

Lung cancer susceptibility refers to the increased likelihood of an individual developing lung cancer due to certain genetic factors or environmental exposures. It is a complex trait influenced by both genetic and environmental factors.

Genetic Factors

Several genes have been identified that may increase lung cancer susceptibility. These include genes involved in DNA repair, cell cycle control, and carcinogen metabolism. Some of the most well-studied genes include TP53, KRAS, and EGFR. Mutations in these genes can lead to uncontrolled cell growth and division, a hallmark of cancer.

Environmental Factors

Environmental factors that increase lung cancer susceptibility include exposure to tobacco smoke, radon, asbestos, and certain air pollutants. Tobacco smoke is the most significant risk factor, responsible for approximately 85% of all lung cancer cases.

Prevention and Screening

Prevention strategies for lung cancer primarily focus on reducing exposure to risk factors. This includes smoking cessation, reducing exposure to radon and asbestos, and improving air quality. Screening for lung cancer in high-risk individuals can also help detect the disease at an early stage when it is more treatable.

Research

Research into lung cancer susceptibility is ongoing, with scientists working to identify new genetic risk factors and to better understand how these interact with environmental exposures. This research could lead to new strategies for prevention and treatment.

See Also

• Cancer genetics
• Cancer epidemiology
• Lung cancer screening
• Smoking and health