MAP4K3

MAP4K3 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3) is a protein that in humans is encoded by the MAP4K3 gene. This protein is a member of the serine/threonine protein kinase family and is known to play a crucial role in cellular processes such as cell growth, cell differentiation, and apoptosis.

Function

MAP4K3 is a kinase that activates the NF-kappaB pathway via BCL10, a process that is essential for the immune response to pathogens. It also plays a role in the regulation of cell proliferation and apoptosis, and is involved in tumorigenesis.

Clinical significance

Alterations in the MAP4K3 gene have been associated with various types of cancer, including breast cancer, lung cancer, and colorectal cancer. In addition, MAP4K3 has been implicated in the pathogenesis of rheumatoid arthritis and autoimmune diseases.

Structure

The MAP4K3 protein consists of a protein kinase domain at the N-terminus, followed by a CNH domain and a PH domain at the C-terminus. The protein kinase domain is responsible for the catalytic activity of the protein, while the CNH and PH domains are involved in protein-protein interactions.

Interactions

MAP4K3 has been shown to interact with TRAF2, TRAF6, and BCL10. These interactions are crucial for the activation of the NF-kappaB pathway.

See also

• Mitogen-activated protein kinase
• Serine/threonine-specific protein kinase
• Protein kinase