MDPI
MCPG
MCPG, or (RS)-α-Methyl-4-carboxyphenylglycine, is a chemical compound that acts as a selective antagonist of metabotropic glutamate receptors (mGluRs). It is widely used in neuroscience research to study the role of mGluRs in synaptic transmission and plasticity.
Structure and Properties[edit | edit source]
MCPG is a derivative of phenylglycine, characterized by the presence of a methyl group and a carboxyl group on the phenyl ring. Its chemical formula is C10H11NO4, and it has a molecular weight of 209.20 g/mol. The compound is typically used in its racemic form, which contains both R and S enantiomers.
Mechanism of Action[edit | edit source]
MCPG functions as a competitive antagonist at metabotropic glutamate receptors, particularly mGluR1 and mGluR5 subtypes. By binding to these receptors, MCPG inhibits the action of glutamate, the primary excitatory neurotransmitter in the central nervous system. This inhibition affects various intracellular signaling pathways, including those involving phospholipase C and inositol trisphosphate (IP3).
Applications in Research[edit | edit source]
MCPG is extensively used in experimental settings to investigate the physiological and pathological roles of mGluRs. It has been instrumental in:
- Studying Synaptic Plasticity: MCPG is used to explore the mechanisms underlying long-term potentiation (LTP) and long-term depression (LTD), which are critical for learning and memory.
- Neuroprotection Studies: Researchers use MCPG to assess the potential neuroprotective effects of mGluR antagonism in models of neurodegenerative diseases such as Alzheimer's and Parkinson's disease.
- Pain Research: MCPG helps in understanding the role of mGluRs in pain perception and the development of chronic pain conditions.
Safety and Handling[edit | edit source]
As with many research chemicals, MCPG should be handled with care. Appropriate safety measures, including the use of personal protective equipment (PPE) and working in a well-ventilated area, are recommended to minimize exposure.
Also see[edit | edit source]
- Metabotropic glutamate receptor
- Glutamate (neurotransmitter)
- Synaptic plasticity
- Neurotransmitter receptor
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Contributors: Prab R. Tumpati, MD
