MLX (gene)
MLX (gene) is a gene that encodes the Max-like protein X in humans. The MLX gene is located on the long (q) arm of chromosome 17 at position 12. The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZip) family, and can form homodimers or heterodimers with other bHLHZip proteins.
Function[edit | edit source]
The MLX protein is a transcription factor that plays a crucial role in the regulation of metabolic homeostasis. It is involved in the control of glucose and lipid metabolism, and its dysregulation can lead to metabolic disorders such as diabetes and obesity.
Clinical significance[edit | edit source]
Mutations in the MLX gene have been associated with a higher risk of developing type 2 diabetes. Moreover, the MLX protein has been implicated in the regulation of autophagy, a process that is often disrupted in cancer cells. Therefore, MLX is considered a potential therapeutic target for metabolic diseases and cancer.
See also[edit | edit source]
References[edit | edit source]
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