Methicillin sodium
Methicillin Sodium is a semi-synthetic penicillin derivative that was once widely used as an antibiotic to treat infections caused by Staphylococcus aureus bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). It is no longer in clinical use due to the prevalence of resistance.
History[edit | edit source]
Methicillin Sodium was developed by Beecham Group in the United Kingdom in 1959, in response to the need for an antibiotic that could combat penicillin-resistant Staphylococcus aureus. It was the first of the beta-lactamase-resistant penicillins to be discovered.
Mechanism of Action[edit | edit source]
Methicillin Sodium works by inhibiting the final stage of bacterial cell wall synthesis, leading to cell death. It does this by binding to and inactivating penicillin-binding proteins (PBPs) on the inner surface of the bacterial cell membrane.
Resistance[edit | edit source]
Resistance to Methicillin Sodium is primarily due to the acquisition of a new PBP, known as PBP2a, which has a low affinity for beta-lactam antibiotics. This is encoded by the mecA gene, which is carried on a mobile genetic element called the staphylococcal cassette chromosome mec (SCCmec).
Side Effects[edit | edit source]
Common side effects of Methicillin Sodium include rash, nausea, vomiting, and diarrhea. Serious side effects can include anaphylaxis, kidney failure, and neutropenia.
See Also[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
