Mexazolam

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Mexazolam is a benzodiazepine derivative with anxiolytic, anticonvulsant, sedative, and muscle relaxant properties. It is primarily used in the treatment of anxiety disorders and insomnia. Mexazolam is known for its relatively long half-life and is metabolized in the liver.

Pharmacology

Mexazolam works by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor, which results in its calming effects. This mechanism is similar to that of other benzodiazepines, such as diazepam and alprazolam.

Medical Uses

Mexazolam is prescribed for:

• Anxiety disorders
• Insomnia
• Muscle spasms
• Seizure control

Side Effects

Common side effects of mexazolam include:

• Drowsiness
• Dizziness
• Fatigue
• Muscle weakness
• Ataxia

Contraindications

Mexazolam should not be used in individuals with:

• Severe respiratory insufficiency
• Sleep apnea
• Severe hepatic impairment
• Myasthenia gravis
• Known hypersensitivity to benzodiazepines

Dependence and Withdrawal

As with other benzodiazepines, long-term use of mexazolam can lead to physical dependence and withdrawal syndrome. Symptoms of withdrawal may include anxiety, insomnia, tremors, and, in severe cases, seizures.

Legal Status

The legal status of mexazolam varies by country. In some regions, it is classified as a controlled substance due to its potential for abuse and dependence.

See Also

• Benzodiazepine
• Anxiolytic
• Sedative
• Anticonvulsant
• Muscle relaxant