Nealbarbital

Nealbarbital is a barbiturate derivative that was first synthesized in the early 20th century. It is a central nervous system depressant with sedative and hypnotic properties.

History

Nealbarbital was first synthesized in the early 20th century as part of a series of barbiturates, a class of drugs that were widely used for their sedative and hypnotic effects. The barbiturates were first discovered in 1864 and were used extensively in the first half of the 20th century for the treatment of insomnia, anxiety, and seizure disorders.

Pharmacology

Like other barbiturates, Nealbarbital works by increasing the activity of the inhibitory neurotransmitter GABA in the brain. This results in a decrease in nerve cell activity, leading to sedation and a decrease in anxiety.

Medical Uses

Nealbarbital has been used for the treatment of insomnia and anxiety. It has also been used as a premedication for surgery to reduce anxiety and induce sedation. However, due to the risk of dependence and the development of more effective and safer drugs, it is no longer commonly used.

Side Effects and Risks

Common side effects of Nealbarbital include drowsiness, dizziness, and impaired coordination. More serious side effects can include respiratory depression, dependence, and withdrawal symptoms upon discontinuation.

Due to the risk of dependence and the availability of safer alternatives, Nealbarbital and other barbiturates are now rarely used. They are considered drugs of last resort for the treatment of insomnia and anxiety.

See Also

• Barbiturates
• GABA
• Insomnia
• Anxiety