Neurocutaneous melanosis
Neurocutaneous melanosis (NCM) is a rare, congenital, non-inherited condition characterized by the presence of large or numerous melanocytic nevi (pigmented skin lesions) and melanotic lesions of the central nervous system. The condition is often associated with a high risk of malignant melanoma, a type of skin cancer.
Signs and Symptoms[edit | edit source]
The most common sign of neurocutaneous melanosis is the presence of large or numerous melanocytic nevi, often present at birth or appearing in early childhood. These nevi can vary in size and are typically larger than 20mm in diameter. They are often found on the trunk, scalp, or limbs.
In addition to skin lesions, individuals with neurocutaneous melanosis may also have neurological symptoms. These can include seizures, developmental delay, intellectual disability, and neurological deficits. These symptoms are typically a result of melanotic lesions in the central nervous system.
Diagnosis[edit | edit source]
Diagnosis of neurocutaneous melanosis is typically made based on the presence of characteristic skin lesions and neurological symptoms. Magnetic resonance imaging (MRI) can be used to identify melanotic lesions in the central nervous system. In some cases, a biopsy of the skin lesions may be performed to confirm the diagnosis.
Treatment[edit | edit source]
There is currently no cure for neurocutaneous melanosis. Treatment is typically focused on managing symptoms and monitoring for the development of malignant melanoma. This can include regular skin examinations, neurological assessments, and imaging studies. In some cases, surgical removal of large or symptomatic skin lesions may be recommended.
Prognosis[edit | edit source]
The prognosis for individuals with neurocutaneous melanosis varies. The condition is associated with a high risk of malignant melanoma, which can significantly impact prognosis. Early detection and treatment of malignant melanoma can improve prognosis.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
