Orbital lymphoma

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC

Orbital lymphoma
Synonyms	N/A
Pronounce	N/A
Specialty	N/A
Symptoms	Proptosis, diplopia, vision loss, eyelid swelling
Complications	Vision impairment, orbital cellulitis
Onset	Typically in adulthood
Duration	Variable, depending on treatment
Types	MALT lymphoma, Diffuse large B-cell lymphoma, Follicular lymphoma
Causes	Genetic mutations, environmental factors
Risks	Age, immunosuppression, autoimmune diseases
Diagnosis	Biopsy, imaging studies
Differential diagnosis	Orbital pseudotumor, thyroid eye disease, orbital cellulitis
Prevention	N/A
Treatment	Radiation therapy, chemotherapy, surgery
Medication	N/A
Prognosis	Generally good with treatment, varies by type
Frequency	Rare
Deaths	N/A

Orbital lymphoma is a type of non-Hodgkin lymphoma that occurs in the orbit, the bony cavity in the skull where the eye and its appendages are situated. It is a rare condition that can affect the eye socket, leading to various ocular and systemic symptoms.

Pathophysiology

Orbital lymphoma is characterized by the proliferation of malignant lymphocytes within the orbital tissues. The most common type of orbital lymphoma is mucosa-associated lymphoid tissue (MALT) lymphoma, but other types such as diffuse large B-cell lymphoma and follicular lymphoma can also occur.

Clinical Presentation

Patients with orbital lymphoma may present with a variety of symptoms, including:

• Proptosis (bulging of the eye)
• Diplopia (double vision)
• Ptosis (drooping of the eyelid)
• Vision impairment
• Periorbital swelling

These symptoms result from the mass effect of the lymphoma within the confined space of the orbit.

Diagnosis

The diagnosis of orbital lymphoma typically involves:

• Clinical examination
• Imaging studies such as CT scan or MRI of the orbit
• Biopsy of the orbital mass for histopathological examination

Treatment

Treatment options for orbital lymphoma depend on the type and stage of the lymphoma and may include:

• Radiation therapy
• Chemotherapy
• Immunotherapy

In some cases, a combination of these treatments may be used to achieve the best outcome.

Prognosis

The prognosis for patients with orbital lymphoma varies depending on the type and stage of the disease. MALT lymphoma generally has a good prognosis with appropriate treatment, while more aggressive types like diffuse large B-cell lymphoma may have a more guarded prognosis.

See also

• Lymphoma
• Non-Hodgkin lymphoma
• Eye diseases
• Ophthalmology