PC3
PC3 is a human prostate cancer cell line used in medical research. It is one of the cell lines most commonly used in the field of oncology. PC3 cells are known for their high level of invasiveness and metastatic potential.
History[edit | edit source]
PC3 was established in 1979 from bone metastasis of grade IV prostatic adenocarcinoma from a 62-year-old Caucasian male. The cell line has been used extensively in research, particularly in the study of prostate cancer and metastasis.
Characteristics[edit | edit source]
PC3 cells are epithelial in morphology, lack androgen receptors and do not respond to androgens. They are also resistant to Fas ligand and TNF-related apoptosis-inducing ligand (TRAIL) induced apoptosis. PC3 cells are highly invasive and metastatic, which makes them a useful model for studying the mechanisms of prostate cancer progression and metastasis.
Use in Research[edit | edit source]
PC3 cells are used in a variety of research applications, including the study of cancer cell biology, drug resistance, tumor growth, and metastasis. They are also used in the development and testing of new therapeutic strategies for prostate cancer.
References[edit | edit source]
See Also[edit | edit source]
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