PKNOX1
PKNOX1 (PBX/knotted 1 homeobox 1) is a gene that encodes a transcription factor involved in the regulation of gene expression. This gene is located on chromosome 21 in humans.
Function[edit | edit source]
PKNOX1 is a member of the homeobox gene family, which plays a crucial role in the regulation of developmental processes. The protein encoded by PKNOX1 is a transcription factor that interacts with other homeodomain proteins to regulate the expression of target genes. It is involved in various biological processes, including cell differentiation, organogenesis, and embryonic development.
Clinical Significance[edit | edit source]
Mutations or dysregulation of PKNOX1 have been implicated in several diseases and disorders. Research suggests that alterations in PKNOX1 expression may contribute to the development of certain types of cancer, as well as developmental disorders.
Interactions[edit | edit source]
PKNOX1 interacts with other proteins to form complexes that regulate gene expression. It is known to interact with PBX1, another homeobox protein, to modulate the transcription of target genes. These interactions are essential for the proper functioning of the transcriptional regulatory network in cells.
Research[edit | edit source]
Ongoing research is focused on understanding the precise role of PKNOX1 in human health and disease. Studies are investigating its potential as a therapeutic target for the treatment of diseases associated with its dysregulation.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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Contributors: Prab R. Tumpati, MD