PKNOX1

PKNOX1 is a gene that encodes a member of the PBX/knotted 1 homeobox family. The encoded protein functions as a transcription factor and may play a role in development and cell differentiation. The protein can form a complex with other transcription factors to regulate gene expression.

Function

The PKNOX1 gene provides instructions for making a protein that is involved in the regulation of gene expression, which is the process by which information from a gene is used in the synthesis of a functional gene product. This protein is a member of the PBX/knotted 1 homeobox family, and it can form a complex with other transcription factors to regulate gene expression. The PKNOX1 protein may play a role in development and cell differentiation.

Clinical significance

Mutations in the PKNOX1 gene have been associated with certain types of cancer, including leukemia and colorectal cancer. The PKNOX1 protein is thought to act as a tumor suppressor, which means it helps control the growth and division of cells. When the PKNOX1 gene is mutated, the protein may not function properly, which can lead to the development of cancer.

Research

Research is ongoing to better understand the role of the PKNOX1 gene and its associated protein in development, cell differentiation, and cancer. This research may lead to new treatments for diseases associated with mutations in the PKNOX1 gene.

File:PKNOX1 gene location on human chromosome 21.png

Location of the PKNOX1 gene on human chromosome 21.

See also

• Homeobox
• Transcription factor
• Gene expression
• Tumor suppressor