PRDM2

PRDM2 is a gene that encodes a protein in humans. This protein is a member of the PRDM family of proteins, which are involved in a variety of biological processes, including cell differentiation, cell growth, and tumor suppression.

Function

The PRDM2 protein is a histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. Histone H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression. The protein also represses transcription by binding to the zinc finger DNA-binding domain of transcription factor E2F1. It is also involved in the cell cycle regulation and apoptosis.

Clinical significance

Mutations in the PRDM2 gene have been associated with several types of cancer, including breast cancer, colorectal cancer, and lung cancer. The protein encoded by this gene is thought to play a role in the suppression of tumor growth, and alterations in the function of this protein could contribute to the development of cancer.

Research

Research into the PRDM2 gene and its associated protein is ongoing, with scientists seeking to better understand its function and its role in disease. This research could potentially lead to new treatments for cancer and other diseases.

See also

• PR domain
• PRDM1
• PRDM3
• PRDM4
• PRDM5
• PRDM6
• PRDM7
• PRDM8
• PRDM9
• PRDM10
• PRDM11
• PRDM12
• PRDM13
• PRDM14
• PRDM15
• PRDM16