Pancreatic polypeptide receptor 1
Pancreatic polypeptide receptor 1 (PPR1), also known as Neuropeptide Y receptor type 4 (NPY4R), is a protein that in humans is encoded by the NPY4R gene. This receptor is a member of the neuropeptide Y receptors family, which are G protein-coupled receptors involved in various biological processes.
Function[edit | edit source]
PPR1 is a receptor for pancreatic polypeptide (PP), a hormone secreted by the pancreas. PP is involved in the regulation of pancreatic secretion, gastrointestinal motility, and energy metabolism. The binding of PP to PPR1 triggers a series of intracellular events, including the activation of adenylate cyclase and phospholipase C, leading to changes in cAMP levels and calcium influx.
Clinical significance[edit | edit source]
Alterations in the function of PPR1 have been associated with various diseases. For example, mutations in the NPY4R gene have been linked to obesity and type 2 diabetes. In addition, PPR1 has been implicated in the regulation of appetite and food intake, making it a potential target for the treatment of eating disorders and obesity.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
