Parathyroid hormone 1 receptor
Parathyroid hormone 1 receptor (PTH1R) is a protein that in humans is encoded by the PTH1R gene. It is a member of the G protein-coupled receptor family and is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-related protein (PTHrP).
Function[edit | edit source]
The PTH1R is found in high concentrations in bone and kidney, and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C. In bone, PTH1R is expressed on the surface of osteoblasts, where it is involved in promoting bone turnover. In the kidney, it is involved in calcium reabsorption and phosphate excretion.
Clinical significance[edit | edit source]
Mutations in the PTH1R gene are associated with Jansen's metaphyseal chondrodysplasia and Blomstrand chondrodysplasia, two rare skeletal disorders. In addition, PTH1R has been implicated in the pathogenesis of osteoporosis and other disorders of bone metabolism.
See also[edit | edit source]
- Parathyroid hormone
- Parathyroid hormone-related protein
- G protein-coupled receptor
- Jansen's metaphyseal chondrodysplasia
- Blomstrand chondrodysplasia
References[edit | edit source]
External links[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
