Paterson-Kelly syndrome
Paterson-Kelly syndrome Paterson-Kelly syndrome, also known as Plummer-Vinson syndrome, is a rare disorder characterized by the triad of dysphagia, iron-deficiency anemia, and esophageal webs. This condition predominantly affects middle-aged women and is associated with an increased risk of developing esophageal cancer.
Signs and Symptoms[edit | edit source]
The primary symptoms of Paterson-Kelly syndrome include:
- Dysphagia (difficulty swallowing)
- Iron-deficiency anemia
- Presence of esophageal webs
Other symptoms may include:
- Glossitis (inflammation of the tongue)
- Cheilosis (cracks at the corners of the mouth)
- Koilonychia (spoon-shaped nails)
- Fatigue and weakness
Causes[edit | edit source]
The exact cause of Paterson-Kelly syndrome is unknown. However, it is believed to be related to chronic iron deficiency. The development of esophageal webs is thought to be due to the iron deficiency affecting the epithelial cells of the esophagus.
Diagnosis[edit | edit source]
Diagnosis of Paterson-Kelly syndrome is typically based on clinical presentation and confirmed through:
- Barium swallow radiography
- Endoscopy
- Blood tests showing iron-deficiency anemia
Treatment[edit | edit source]
Treatment for Paterson-Kelly syndrome focuses on addressing the iron deficiency and relieving the dysphagia. This may include:
- Iron supplementation
- Dietary modifications
- Dilation of esophageal webs through endoscopic procedures
Prognosis[edit | edit source]
With appropriate treatment, the prognosis for individuals with Paterson-Kelly syndrome is generally good. However, regular monitoring is necessary due to the increased risk of developing esophageal cancer.
Related Pages[edit | edit source]
Categories[edit | edit source]
Paterson-Kelly syndrome Resources | |
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