Pdz domain containing 9

Ideogram human chromosome 16

The PDZ domain containing 9 is a protein domain that plays a crucial role in protein-protein interactions within cells. This domain is found in a variety of proteins and is involved in the organization of signaling complexes and the regulation of cellular processes.

Structure

The PDZ domain containing 9 is characterized by its conserved structural features, including a beta sandwich fold composed of six beta strands and two alpha helices. This domain typically binds to specific short amino acid sequences at the C-terminus of target proteins, facilitating the formation of protein complexes.

Function

The PDZ domain containing 9 functions as a scaffold for assembling protein complexes involved in various cellular processes, such as cell signaling, cell adhesion, and protein trafficking. By interacting with specific target proteins, this domain helps regulate the localization and activity of these proteins within the cell.

Role in Disease

Mutations or dysregulation of PDZ domain containing 9 have been associated with certain diseases, including cancer and neurological disorders. Understanding the role of this domain in disease pathogenesis may provide insights into potential therapeutic strategies targeting protein-protein interactions.

Research

Research on the PDZ domain containing 9 continues to uncover its diverse functions and implications in cellular physiology and pathology. Studies investigating the molecular mechanisms underlying the interactions mediated by this domain contribute to our understanding of complex biological processes.

Cell biology