Pheneturide

Pheneturide.svg

Pheneturide is a medication primarily used in the treatment of epilepsy. It is a derivative of phenobarbital and is known for its anticonvulsant properties. Pheneturide is also referred to by its chemical name, 3-ethyl-3-phenylhydantoin.

Pharmacology

Pheneturide works by stabilizing the neuronal membranes and reducing the spread of seizure activity in the brain. It is believed to enhance the action of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, thereby exerting its anticonvulsant effects.

Indications

Pheneturide is indicated for the management of various types of seizures, including tonic-clonic seizures and partial seizures. It is often used when other anticonvulsant medications are not effective or cause unacceptable side effects.

Side Effects

Common side effects of pheneturide include drowsiness, dizziness, and ataxia. In some cases, it may cause nausea, vomiting, and allergic reactions. Long-term use can lead to tolerance and dependence.

Dosage

The dosage of pheneturide is individualized based on the patient's response and the severity of the condition. It is usually administered orally, and the dose is gradually increased to minimize side effects.

Contraindications

Pheneturide is contraindicated in patients with a history of hypersensitivity to the drug or its components. It should be used with caution in patients with liver disease, kidney disease, or porphyria.

Interactions

Pheneturide can interact with other medications, including other anticonvulsants, antidepressants, and anticoagulants. These interactions can alter the effectiveness of pheneturide or increase the risk of side effects.

History

Pheneturide was first synthesized in the mid-20th century as a derivative of phenobarbital. It was developed to provide an alternative treatment option for patients with epilepsy who did not respond well to other medications.

See Also

• Epilepsy
• Anticonvulsant
• Phenobarbital
• Gamma-aminobutyric acid