Plummer-Vinson syndrome
Plummer-Vinson syndrome (PVS), also known as Paterson-Brown-Kelly syndrome or sideropenic dysphagia, is a rare medical condition characterized by a triad of dysphagia (difficulty swallowing), iron-deficiency anemia, and esophageal webs.
Etiology[edit | edit source]
The exact cause of Plummer-Vinson syndrome is unknown. However, it is often associated with chronic iron deficiency anemia. It is believed that the syndrome may be the result of a long-standing iron deficiency, which can lead to tissue weakness and atrophy in the upper digestive tract.
Symptoms[edit | edit source]
The primary symptoms of Plummer-Vinson syndrome include dysphagia (difficulty swallowing), iron-deficiency anemia, and the presence of esophageal webs. Other symptoms may include glossitis (inflammation of the tongue), cheilosis (inflammation of the lips), and koilonychia (spoon-shaped nails).
Diagnosis[edit | edit source]
Diagnosis of Plummer-Vinson syndrome is typically made based on the presence of the classic triad of symptoms. Additional diagnostic tests may include endoscopy to visualize the esophageal webs, and blood tests to confirm iron-deficiency anemia.
Treatment[edit | edit source]
Treatment for Plummer-Vinson syndrome primarily involves addressing the iron deficiency with iron supplements. In some cases, dilation of the esophagus may be necessary to alleviate dysphagia.
Epidemiology[edit | edit source]
Plummer-Vinson syndrome is rare and is more commonly seen in women than in men. It is most frequently diagnosed in middle-aged individuals, and the incidence appears to be decreasing over time.
Prognosis[edit | edit source]
With appropriate treatment, the prognosis for individuals with Plummer-Vinson syndrome is generally good. However, there is an increased risk of developing esophageal cancer and pharyngeal cancer in individuals with this syndrome.
See also[edit | edit source]
NIH genetic and rare disease info[edit source]
Plummer-Vinson syndrome is a rare disease.
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