Polypoid melanoma

A subtype of melanoma characterized by polypoid growth

Polypoid melanoma is a rare and aggressive subtype of melanoma, a form of skin cancer that arises from the pigment-producing melanocytes. This variant is distinguished by its polypoid or nodular growth pattern, which can lead to a more rapid progression compared to other forms of melanoma.

Pathophysiology

Polypoid melanoma is characterized by its unique growth pattern, where the tumor forms a protruding mass above the skin surface. This is due to the vertical growth phase of the melanoma cells, which proliferate rapidly and invade deeper into the dermis. The polypoid structure is often associated with a higher mitotic rate and increased potential for metastasis.

Clinical Presentation

Polypoid melanoma on the skin

Patients with polypoid melanoma typically present with a rapidly growing, dome-shaped lesion that may be pigmented or amelanotic. These lesions are often larger than other types of melanoma at the time of diagnosis and may ulcerate or bleed. Due to their aggressive nature, early detection and treatment are crucial.

Diagnosis

The diagnosis of polypoid melanoma is primarily based on biopsy and histopathological examination. The biopsy will reveal a nodular growth pattern with a high density of atypical melanocytes. Immunohistochemical staining can aid in confirming the diagnosis by highlighting melanoma-specific markers such as S-100 protein, HMB-45, and Melan-A.

Treatment

The primary treatment for polypoid melanoma is surgical excision with wide margins to ensure complete removal of the tumor. Due to the aggressive nature of this melanoma subtype, additional treatments such as immunotherapy, targeted therapy, or chemotherapy may be considered, especially in cases where there is evidence of metastasis.

Prognosis

The prognosis for polypoid melanoma is generally poorer than for other types of melanoma due to its rapid growth and higher likelihood of metastasis. Early detection and treatment are critical to improving outcomes. Regular follow-up and monitoring for recurrence or spread are essential components of patient management.

Related pages

• Melanoma
• Skin cancer
• Dermatology
• Oncology