Posterior polymorphous corneal dystrophy

Posterior Polymorphous Corneal Dystrophy (PPCD) is a rare genetic disorder that affects the cornea of the eye. It is characterized by changes in the innermost layer of the cornea, known as the endothelium. These changes can lead to a variety of symptoms, including blurred vision, glare, and in severe cases, loss of vision.

Symptoms and Signs[edit | edit source]

The symptoms of PPCD can vary greatly from person to person. Some individuals may have no symptoms at all, while others may experience significant vision problems. Common symptoms include:

Blurred vision
Glare
Halos around lights
Pain or discomfort in the eye
Decreased visual acuity

Causes[edit | edit source]

PPCD is caused by mutations in the COL8A2 and ZEB1 genes. These genes are involved in the development and function of the cornea. Mutations in these genes can lead to the abnormal development of the cornea, resulting in the symptoms of PPCD.

Diagnosis[edit | edit source]

The diagnosis of PPCD is typically made based on a thorough eye examination, including a slit lamp examination. This examination allows the doctor to view the inner structures of the eye and identify any abnormalities. Genetic testing may also be performed to confirm the diagnosis.

Treatment[edit | edit source]

There is currently no cure for PPCD. Treatment is focused on managing the symptoms and preventing further damage to the cornea. This may include the use of eye drops to reduce inflammation and discomfort, or in severe cases, corneal transplantation may be necessary.

References[edit | edit source]

Template:Eye-diseases-stub Template:Genetic-disorders-stub Template:Rare-diseases-stub

Posterior polymorphous corneal dystrophy Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.