Propenidazole

Propenidazole.svg

Propenidazole is an antiprotozoal medication used primarily in the treatment of trichomoniasis, a sexually transmitted infection caused by the protozoan Trichomonas vaginalis. It belongs to the class of drugs known as nitroimidazoles, which are effective against a variety of anaerobic organisms.

Mechanism of Action

Propenidazole works by inhibiting the synthesis of nucleic acids in the protozoa, leading to cell death. The drug is activated by reduction within the anaerobic cell, which then interacts with the DNA of the microorganism, causing strand breakage and ultimately cell death.

Uses

Propenidazole is primarily indicated for the treatment of trichomoniasis. It may also be used off-label for other protozoal infections, although its use is less common compared to other nitroimidazoles like metronidazole and tinidazole.

Side Effects

Common side effects of propenidazole include:

• Nausea
• Vomiting
• Diarrhea
• Headache
• Dizziness

Serious side effects are rare but may include:

• Allergic reactions
• Seizures
• Peripheral neuropathy

Contraindications

Propenidazole should not be used in individuals with a known hypersensitivity to nitroimidazoles. It is also contraindicated in patients with severe liver impairment due to the drug's metabolism in the liver.

Pharmacokinetics

Propenidazole is well absorbed from the gastrointestinal tract and is widely distributed in body tissues. It is metabolized in the liver and excreted primarily in the urine.

History

Propenidazole was developed as part of the search for effective treatments for protozoal infections. Its development followed the success of other nitroimidazoles, which have been used extensively in the treatment of anaerobic infections.

See Also

• Trichomoniasis
• Nitroimidazole
• Metronidazole
• Tinidazole