Propiomazine
(Redirected from Propiomazine hydrochloride)
Propiomazine is a phenothiazine derivative with antihistamine and sedative properties. It is primarily used in the treatment of insomnia and as a premedication before surgery due to its calming effects. Propiomazine is known for its ability to block histamine H1 receptors, which contributes to its sedative effects.
Pharmacology[edit | edit source]
Propiomazine works by antagonizing the histamine H1 receptors, which leads to its sedative and hypnotic effects. Additionally, it has some anticholinergic properties, which can contribute to its overall calming effect. The drug is metabolized in the liver and excreted through the kidneys.
Medical Uses[edit | edit source]
Propiomazine is used for:
- Treating insomnia
- Preoperative sedation
- Alleviating anxiety in patients undergoing medical procedures
Side Effects[edit | edit source]
Common side effects of propiomazine include:
Serious side effects may include:
Contraindications[edit | edit source]
Propiomazine should not be used in patients with:
- Known hypersensitivity to phenothiazines
- Severe liver disease
- Glaucoma
- Prostatic hypertrophy
Interactions[edit | edit source]
Propiomazine can interact with other medications, including:
Dosage[edit | edit source]
The dosage of propiomazine varies depending on the condition being treated and the patient's response to the medication. It is typically administered orally in tablet form.
History[edit | edit source]
Propiomazine was developed as part of the phenothiazine class of drugs, which were initially discovered for their antipsychotic properties. Over time, the sedative effects of propiomazine were recognized, leading to its use in treating insomnia and as a preoperative sedative.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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