Proxibarbital

Proxibarbital is a barbiturate derivative that is used as a sedative. It is classified as a short-acting barbiturate, which means it has a rapid onset of action and a relatively short duration of effect. Proxibarbital is also known by its trade name, Ipronal.

Pharmacology[edit | edit source]

Proxibarbital works by enhancing the action of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. GABA inhibits the activity of certain brain cells, leading to a decrease in nervous tension (anxiety) and muscle spasms, and an increase in relaxation and sleepiness.

Uses[edit | edit source]

Proxibarbital is used for the short-term treatment of insomnia. It is also used to relieve anxiety and tension, and to control seizures. In addition, it is used as a premedication before surgery to induce sedation, relieve anxiety, and decrease recall of the procedure.

Side Effects[edit | edit source]

Common side effects of proxibarbital include drowsiness, dizziness, and loss of coordination. Less common side effects include headache, nausea, vomiting, constipation, and skin rash. Serious side effects can occur if the drug is used in high doses or for a long period of time, including dependency, withdrawal symptoms, and severe skin reactions.

Contraindications[edit | edit source]

Proxibarbital is contraindicated in patients with a history of hypersensitivity to barbiturates, in patients with a history of drug abuse, and in patients with certain types of respiratory disease. It should be used with caution in elderly patients and in patients with kidney or liver disease.

See Also[edit | edit source]

Proxibarbital Resources
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