Retinoic acid receptor beta
Retinoic acid receptor beta (RAR-beta), also known as NR1B2 (nuclear receptor subfamily 1, group B, member 2), is a nuclear receptor that in humans is encoded by the RAR-beta gene.
Function[edit | edit source]
Retinoic acid receptor beta is a receptor for retinoic acid. This receptor is a member of the nuclear receptor family, a group of transcription factors that are activated by the binding of their ligands. The retinoic acid receptors (RARs) are ligand-dependent, DNA-binding proteins that regulate gene expression by binding to retinoic acid response elements (RAREs) in the promoters of target genes.
Structure[edit | edit source]
The RAR-beta protein has a modular structure and is composed of several domains. The A/B domain is located at the N-terminus and is responsible for ligand-independent activation. The C domain, also known as the DNA-binding domain (DBD), binds to specific sequences of DNA. The D domain, or hinge region, connects the DBD to the E/F domain. The E/F domain, also known as the ligand-binding domain (LBD), binds to retinoic acid and is responsible for ligand-dependent activation.
Clinical significance[edit | edit source]
Alterations in the expression of this receptor are associated with acute promyelocytic leukemia, squamous cell carcinoma of the head and neck, and lung cancer. In addition, lower levels of RAR-beta expression have been linked to a poorer prognosis in several types of cancer.
See also[edit | edit source]
References[edit | edit source]
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