Ro48-8684

Ro48-8684 is a nonbenzodiazepine of the imidazopyridine class. It is a sedative and hypnotic drug used in the treatment of insomnia. Ro48-8684 is a GABA_A receptor positive allosteric modulator.

Pharmacology

Ro48-8684 acts as a full agonist at the benzodiazepine site of the GABA_A receptor. It has a high binding affinity for the alpha1 and alpha5 subunits of the GABA_A receptor. The drug enhances the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor, resulting in sedative, sleep-inducing (hypnotic), anxiolytic, anticonvulsant, and muscle relaxant properties.

Medical uses

Ro48-8684 is primarily used for the short-term treatment of insomnia. It helps to decrease the time to sleep onset and increase the duration of sleep.

Side effects

Like other nonbenzodiazepines, Ro48-8684 can cause side effects such as dizziness, headache, nausea, and somnolence. In rare cases, it can cause serious side effects such as memory impairment, hallucinations, and complex sleep-related behaviors.

See also

• Zolpidem
• Zaleplon
• Eszopiclone

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