SB-236057

SB-236057 is a pharmacological compound that acts as a selective antagonist for the 5-HT1B receptor. This receptor is a subtype of the 5-HT receptor that binds the neurotransmitter serotonin, also known as 5-hydroxytryptamine (5-HT).

Pharmacology

SB-236057 is a potent and selective 5-HT1B receptor antagonist. It has been used in scientific research to help understand the role of 5-HT1B receptors in various physiological and pathological processes. The compound has a high affinity for the 5-HT1B receptor, meaning it binds strongly to this receptor and blocks its activation by serotonin.

Chemistry

The chemical structure of SB-236057 is characterized by a dihydropyridine core, which is a common structural motif in many pharmacologically active compounds. The compound also contains a phenyl group and a piperazine ring, which contribute to its high affinity for the 5-HT1B receptor.

Applications

Research with SB-236057 has provided insights into the role of 5-HT1B receptors in various physiological processes, including neurotransmission, vasoconstriction, and platelet aggregation. The compound has also been used to investigate the involvement of 5-HT1B receptors in pathological conditions such as migraine, depression, and anxiety disorders.

See also

• 5-HT receptor
• Serotonin
• Antagonist (biochemistry)

References

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