Selenoprotein o
Selenoprotein O is a protein that is encoded by the SELENOO gene in humans. It is a member of the selenoprotein family, which are proteins that include selenocysteine, an amino acid that contains selenium.
Function[edit | edit source]
Selenoprotein O is involved in various cellular processes, including redox homeostasis and mitochondrial function. It is thought to play a role in the antioxidant defense system by participating in the reduction of reactive oxygen species (ROS) and maintaining the redox balance within the cell.
Structure[edit | edit source]
Like other selenoproteins, Selenoprotein O contains a selenocysteine residue, which is encoded by the UGA codon, typically a stop codon. The presence of a SECIS element in the 3' untranslated region of the mRNA allows for the recoding of UGA as selenocysteine, enabling the incorporation of this unique amino acid into the protein.
Clinical significance[edit | edit source]
Mutations or dysregulation of the SELENOO gene may be associated with various diseases, including cancer and neurodegenerative disorders. Research is ongoing to better understand the specific roles of Selenoprotein O in these conditions and its potential as a therapeutic target.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
