Fatal insomnia
(Redirected from Sporadic fatal insomnia)
Fatal Insomnia[edit | edit source]
Fatal insomnia is a rare disorder characterized by difficulty sleeping, which gradually worsens over time. Other symptoms may include speech and coordination problems, as well as dementia. This prion disease of the brain eventually leads to death within months to years.
Signs and Symptoms[edit | edit source]
Fatal insomnia progresses through four stages:
Increasing insomnia, leading to panic attacks, paranoia, and phobias (about 4 months) Hallucinations and panic attacks become noticeable (about 5 months) Complete inability to sleep, accompanied by rapid weight loss (about 3 months) Dementia, unresponsiveness, or muteness, followed by death (about 6 months) Additional symptoms may include profuse sweating, pinpoint pupils, sudden menopause for women or impotence for men, neck stiffness, elevated blood pressure and heart rate, and constipation.
Cause[edit | edit source]
Fatal insomnia is caused by a mutation in the protein PrPC. It has two forms: Fatal Familial Insomnia (FFI), which is autosomal dominant, and Sporadic Fatal Insomnia (sFI), which is due to a non-inherited mutation.
Diagnosis[edit | edit source]
Diagnosis is typically based on a sleep study, PET scan, and genetic testing.
Treatments[edit | edit source]
There is currently no known cure for fatal insomnia. Treatment involves supportive care, and sleeping pills have not been found helpful.
Prognosis[edit | edit source]
The disorder is invariably fatal, with life expectancy ranging from 7 months to 6 years, and an average of 18 months.
Epidemiology[edit | edit source]
Cases of fatal insomnia have been reported in various countries, including Italy, the United States, and the Netherlands. The age of onset varies from 18 to 60 years, with an average of 50.
Fatal insomnia Resources | |
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See also[edit | edit source]
Creutzfeldt-Jakob Disease Prion Diseases Fatal Familial Insomnia Sporadic Fatal Insomnia
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