Steroid 11β-hydroxylase

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Steroid 11β-hydroxylase is an enzyme that catalyzes the hydroxylation of steroids at the 11-beta position. This enzyme is primarily found in the adrenal gland and is a key player in the production of cortisol and aldosterone, two important hormones in the human body.

Function[edit | edit source]

Steroid 11β-hydroxylase is a member of the cytochrome P450 family of enzymes, which are involved in the metabolism of a wide variety of substances, including drugs, toxins, and endogenous compounds such as steroids. Specifically, this enzyme catalyzes the conversion of 11-deoxycortisol to cortisol and 11-deoxycorticosterone to aldosterone.

Cortisol is a hormone that plays a crucial role in the body's response to stress, while aldosterone is involved in regulating the balance of salt and water in the body.

Clinical significance[edit | edit source]

Mutations in the CYP11B1 gene, which encodes the steroid 11β-hydroxylase enzyme, can lead to congenital adrenal hyperplasia, a group of inherited disorders that affect the adrenal glands. These disorders can cause a variety of symptoms, including abnormal growth and development, and problems with the body's ability to respond to stress.

See also[edit | edit source]

References[edit | edit source]


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