T-47D

T-47D is a cell line derived from a human breast cancer patient. It is commonly used in medical research to study the biology of breast cancer and to test potential therapeutic interventions.

History

The T-47D cell line was established in 1970 by Keydar et al. from a pleural effusion of a 54-year-old female with infiltrating ductal carcinoma of the breast. The cells are estrogen receptor positive and progesterone receptor positive.

Characteristics

T-47D cells are epithelial in nature and form adherent monolayers in culture. They express both estrogen receptor (ER) and progesterone receptor (PR), making them a useful model for studying hormone-responsive breast cancers.

Use in Research

T-47D cells are widely used in breast cancer research. They are particularly useful for studying the effects of hormones on breast cancer growth and progression, as they respond to both estrogen and progesterone. They have also been used to study the effects of various therapeutic interventions on breast cancer cells.

See Also

• Breast cancer
• Cell line
• Estrogen receptor
• Progesterone receptor

References

T-47D Resources
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