TRIM28

TRIM28 (also known as Tripartite Motif Containing 28) is a protein that in humans is encoded by the TRIM28 gene. This protein is a universal transcription co-repressor that plays a crucial role in the regulation of both embryonic development and cancer progression.

Function

TRIM28 is a member of the TRIM protein family. It is involved in the control of cell proliferation and DNA damage response. TRIM28 acts as a co-repressor for Krüppel-associated box (KRAB) domain-containing zinc finger proteins (ZFPs). It can also interact with a variety of other proteins, including p53, E2F1, and STAT3, to regulate their activities.

Structure

The TRIM28 protein contains several domains, including a RING finger domain, B-box type 1 and 2 domains, a coiled-coil region, and a plant homeodomain (PHD) finger. The RING finger domain is involved in protein-protein interaction and ubiquitination, while the PHD finger is responsible for binding to histones.

Clinical Significance

Alterations in TRIM28 expression have been associated with various types of cancer, including breast cancer, lung cancer, and colorectal cancer. Overexpression of TRIM28 can lead to increased cell proliferation and resistance to apoptosis, promoting tumor growth. On the other hand, loss of TRIM28 expression can result in genomic instability and increased susceptibility to DNA damage.

File:TRIM28 protein structure.jpg

Structure of the TRIM28 protein.

See Also

• TRIM protein family
• Transcription (genetics)
• Cancer

References

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