Testicular intratubular germ cell neoplasia

Testicular Intratubular Germ Cell Neoplasia (ITGCN) is a pre-invasive stage of testicular germ cell tumors, which are the most common type of cancer in young men. ITGCN is present in the testicles before a germ cell tumor develops.

Epidemiology

ITGCN is found in approximately 5% of men who have a biopsy of the testicle for infertility. It is also found in almost all men with testicular germ cell tumors.

Pathogenesis

ITGCN cells are derived from germ cells that have failed to mature properly. These cells have the potential to develop into all types of germ cell tumors, with the exception of spermatocytic seminomas.

Diagnosis

The diagnosis of ITGCN is made by examining a sample of testicular tissue under a microscope. The presence of ITGCN cells can be confirmed by their characteristic appearance and by the use of immunohistochemical stains.

Treatment

The treatment of ITGCN is usually with chemotherapy or radiation therapy. In some cases, surgical removal of the testicle may be necessary.

Prognosis

The prognosis for men with ITGCN is generally good, as the condition is curable if detected early. However, if left untreated, ITGCN can progress to invasive germ cell tumors.

See also

• Testicular cancer
• Germ cell tumor
• Orchiectomy

Testicular intratubular germ cell neoplasia Resources
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