Testicular intratubular germ cell neoplasia
Testicular Intratubular Germ Cell Neoplasia (ITGCN) is a pre-invasive stage of testicular germ cell tumors, which are the most common type of cancer in young men. ITGCN is present in the testicles before a germ cell tumor develops.
Epidemiology[edit | edit source]
ITGCN is found in approximately 5% of men who have a biopsy of the testicle for infertility. It is also found in almost all men with testicular germ cell tumors.
Pathogenesis[edit | edit source]
ITGCN cells are derived from germ cells that have failed to mature properly. These cells have the potential to develop into all types of germ cell tumors, with the exception of spermatocytic seminomas.
Diagnosis[edit | edit source]
The diagnosis of ITGCN is made by examining a sample of testicular tissue under a microscope. The presence of ITGCN cells can be confirmed by their characteristic appearance and by the use of immunohistochemical stains.
Treatment[edit | edit source]
The treatment of ITGCN is usually with chemotherapy or radiation therapy. In some cases, surgical removal of the testicle may be necessary.
Prognosis[edit | edit source]
The prognosis for men with ITGCN is generally good, as the condition is curable if detected early. However, if left untreated, ITGCN can progress to invasive germ cell tumors.
See also[edit | edit source]
| Testicular intratubular germ cell neoplasia Resources | |
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Contributors: Prab R. Tumpati, MD
