Testifenon
| Testifenon | |
|---|---|
| |
| INN | |
| Drug class | |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
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| Legal status | |
| CAS Number | 104730-58-7 |
| PubChem | 128659 |
| DrugBank | |
| ChemSpider | 114020 |
| KEGG | |
Testifenon, also known as testiphenon, testiphenone, chlorphenacyl dihydrotestosterone ester, or dihydrotestosterone 17β-(4-(bis(2-chloroethyl)amino)phenyl)acetate, is a synthetic anabolic–androgenic steroid (AAS) and a cytostatic antineoplastic agent (i.e., chemotherapeutic) that was never marketed.[1][2][3] It is an androgen ester – specifically, a chlorphenacyl nitrogen mustard ester of dihydrotestosterone (DHT) – and acts as a prodrug of these two components in the body.[1][2] The drug was developed in Russia as a tissue-selective cytostatic drug for the treatment of various cancers occurring in androgen receptor-expressing tissues that would have reduced side effects and toxicity relative to other chemotherapy drugs.[1][2]
See also[edit | edit source]
- List of hormonal cytostatic antineoplastic agents
- List of androgen esters § Dihydrotestosterone esters
References[edit | edit source]
- ↑ 1.0 1.1 1.2 , [The antineoplastic activity of testiphenon], Vopr Onkol, 1988, Vol. 34(Issue: 11), pp. 1363–8, PMID: 3201773,
- ↑ 2.0 2.1 2.2 , Comparative pharmacokinetics of3H-testiphenone and3H-chlorophenacyl in peroral administration to mice, Pharmaceutical Chemistry Journal, 1995, Vol. 29(Issue: 11), pp. 737–739, DOI: 10.1007/BF02331848,
- ↑ , [Pharmacological aspects in the development of liposomal medicinal preparations for the internal injection of hydrophobic cytostatics], Vestn. Akad. Med. Nauk SSSR, 2002, (Issue: 1), pp. 42–5, PMID: 11882971,
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