Tiemonium

Tiemonium Methylsulfate is a quaternary ammonium compound used as an antispasmodic. It is a peripheral anticholinergic agent taken to relieve cramps or spasms of the stomach, intestines, and bladder. It can also be used to treat the symptoms of irritable bowel syndrome.

Pharmacology[edit | edit source]

Tiemonium methylsulfate is a synthetic antispasmodic agent. It exhibits antimuscarinic and anticholinergic properties, thus preventing the passage of calcium ions through the calcium channels of the smooth muscle cells. This action inhibits the contractile process of the smooth muscle cells, relieving spasms.

Indications[edit | edit source]

Tiemonium is indicated for the treatment of gastrointestinal spasm, biliary spasm, ureteric spasm, and other conditions involving smooth muscle spasm. It is also used in the symptomatic relief of irritable bowel syndrome and treatment of postoperative paralytic ileus and functional disorders of gastrointestinal motility.

Side Effects[edit | edit source]

Common side effects of Tiemonium include dry mouth, reduced sweating, blurred vision, and urinary retention. In rare cases, it can cause allergic reactions, tachycardia, and constipation.

Contraindications[edit | edit source]

Tiemonium is contraindicated in patients with myasthenia gravis, prostatic hypertrophy, and glaucoma. It should also be used with caution in elderly patients and those with autonomic neuropathy.

Interactions[edit | edit source]

Tiemonium may interact with other drugs such as antihistamines, tricyclic antidepressants, and phenothiazines, which can enhance the anticholinergic effects of Tiemonium.