Tosagestin

Tosagestin is a progestin medication which was never marketed. It is a synthetic and orally active progestin of the 19-nortestosterone group and was synthesized in 1965.

Pharmacology

Tosagestin, like other progestins, works by binding to and activating the progesterone receptor (PR), an intracellular receptor that is expressed in various tissues like the uterus, cervix, vagina, mammary glands, and brain. Upon activation, the PR modulates the expression of certain genes, leading to changes in the function of these tissues.

Chemistry

Tosagestin is a synthetic progestin and is part of the 19-nortestosterone group. This group also includes other progestins like norethisterone, levonorgestrel, and desogestrel. Tosagestin is a derivative of testosterone, and more specifically, a derivative of nortestosterone (19-nortestosterone).

History

Tosagestin was synthesized in 1965 but was never marketed. The reasons for this are not clear, but it may be due to the development of other, more effective progestins around the same time.

See also

• List of progestogens
• List of androgens/anabolic steroids

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