Tosagestin
Tosagestin is a synthetic progestin that belongs to the class of hormonal contraceptives. It is used in hormone replacement therapy (HRT) and for the treatment of various gynecological disorders.
Pharmacology[edit | edit source]
Tosagestin acts on the progesterone receptors in the body, mimicking the effects of natural progesterone. It helps regulate the menstrual cycle, supports pregnancy, and maintains the early stages of gestation.
Medical Uses[edit | edit source]
Tosagestin is primarily used in:
- Hormone replacement therapy (HRT) for menopausal symptoms
- Treatment of endometriosis
- Management of menstrual disorders such as dysmenorrhea and menorrhagia
- Part of combined oral contraceptives
Side Effects[edit | edit source]
Common side effects of Tosagestin include:
Mechanism of Action[edit | edit source]
Tosagestin binds to progesterone receptors in the reproductive system, mammary glands, hypothalamus, and pituitary gland. This binding inhibits the secretion of gonadotropin-releasing hormone (GnRH) and subsequently reduces the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), preventing ovulation.
History[edit | edit source]
Tosagestin was developed in the late 20th century as part of the search for more effective and safer progestins. It has been used in various formulations for contraception and hormone therapy.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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Contributors: Prab R. Tumpati, MD