Toxic multinodular goitre
Thyroid condition characterized by an enlarged thyroid gland with multiple nodules
| Toxic multinodular goitre | |
|---|---|
| [[File:|250px|alt=|]] | |
| Synonyms | Plummer's disease |
| Pronounce | N/A |
| Field | Endocrinology |
| Symptoms | Hyperthyroidism, goitre, weight loss, tremors, palpitations |
| Complications | Thyroid storm, atrial fibrillation, osteoporosis |
| Onset | |
| Duration | |
| Types | N/A |
| Causes | Iodine deficiency, genetic factors |
| Risks | |
| Diagnosis | Thyroid function tests, ultrasound, radioactive iodine uptake test |
| Differential diagnosis | Graves' disease, thyroiditis |
| Prevention | N/A |
| Treatment | Antithyroid medication, radioactive iodine therapy, thyroidectomy |
| Medication | Methimazole, propylthiouracil |
| Prognosis | |
| Frequency | |
| Deaths | |
Toxic multinodular goitre (TMNG), also known as Plummer's disease, is a condition characterized by an enlarged thyroid gland with multiple nodules that produce excess thyroid hormone, leading to hyperthyroidism. This condition is more common in older adults and in regions with iodine deficiency.
Signs and symptoms[edit | edit source]
The symptoms of toxic multinodular goitre are primarily those of hyperthyroidism and may include:
- Weight loss
- Tremors
- Palpitations
- Heat intolerance
- Increased appetite
- Nervousness
- Goitre (enlarged thyroid gland)
Complications[edit | edit source]
If left untreated, toxic multinodular goitre can lead to serious complications such as:
- Thyroid storm – a life-threatening exacerbation of hyperthyroidism
- Atrial fibrillation – an irregular and often rapid heart rate
- Osteoporosis – weakened bones due to excessive thyroid hormone
Causes[edit | edit source]
The exact cause of toxic multinodular goitre is not fully understood, but it is believed to be related to:
Diagnosis[edit | edit source]
Diagnosis of toxic multinodular goitre typically involves:
- Thyroid function tests – to measure levels of thyroid hormones and thyroid-stimulating hormone (TSH)
- Ultrasound – to visualize the thyroid gland and detect nodules
- Radioactive iodine uptake test – to assess the function of the thyroid nodules
Differential diagnosis[edit | edit source]
Conditions that may present similarly and need to be differentiated from toxic multinodular goitre include:
Treatment[edit | edit source]
Treatment options for toxic multinodular goitre include:
- Antithyroid medication – such as methimazole or propylthiouracil
- Radioactive iodine therapy – to reduce the activity of the thyroid gland
- Thyroidectomy – surgical removal of part or all of the thyroid gland
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
