Triclofos
Triclofos is a sedative and hypnotic medication primarily used for the short-term treatment of insomnia. It is a derivative of chloral hydrate and is known for its effectiveness in inducing sleep. Triclofos is often administered in the form of its sodium salt, triclofos sodium.
Pharmacology[edit | edit source]
Triclofos works by depressing the central nervous system (CNS), leading to sedation and sleep. It is metabolized in the body to trichloroethanol, which is the active metabolite responsible for its sedative effects. The drug has a relatively rapid onset of action and a moderate duration of effect, making it suitable for use as a sleep aid.
Medical Uses[edit | edit source]
Triclofos is primarily prescribed for the short-term management of insomnia, particularly in cases where other treatments have failed or are not suitable. It may also be used in certain medical procedures to induce sedation.
Side Effects[edit | edit source]
Common side effects of triclofos include:
In rare cases, more severe side effects can occur, such as:
Contraindications[edit | edit source]
Triclofos should not be used in individuals with a known hypersensitivity to the drug or its components. It is also contraindicated in patients with severe liver disease, kidney disease, or respiratory disorders.
Interactions[edit | edit source]
Triclofos can interact with other CNS depressants, such as alcohol, benzodiazepines, and opioids, leading to enhanced sedative effects. It is important to inform healthcare providers of all medications being taken to avoid potential interactions.
Dosage and Administration[edit | edit source]
The dosage of triclofos varies depending on the patient's age, weight, and medical condition. It is typically administered orally in liquid form. The exact dosage should be determined by a healthcare professional.
History[edit | edit source]
Triclofos was developed as an alternative to chloral hydrate, offering similar sedative properties with potentially fewer side effects. It has been used in clinical practice for several decades.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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Contributors: Prab R. Tumpati, MD