Triclofos sodium

Triclofos Sodium is a sedative medication primarily used in the treatment of insomnia. It is a derivative of trichloroethanol and is used in the form of its sodium salt.

Pharmacology

Triclofos Sodium acts as a prodrug to trichloroethanol, which has sedative and hypnotic properties. It is metabolized in the liver to produce trichloroethanol, which is the active metabolite responsible for its sedative effects. The onset of action is typically within 30 minutes to an hour after administration, and the duration of action is approximately 6 to 8 hours.

Medical Uses

Triclofos Sodium is primarily used in the treatment of insomnia, particularly in pediatric patients. It is also used in certain diagnostic procedures where sedation is required, such as electroencephalography (EEG).

Side Effects

Common side effects of Triclofos Sodium include drowsiness, dizziness, and nausea. In rare cases, it can cause serious side effects such as respiratory depression, hypotension, and allergic reactions.

Contraindications

Triclofos Sodium is contraindicated in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with severe liver disease, as it is metabolized in the liver.

Interactions

Triclofos Sodium may interact with other CNS depressants, including alcohol, benzodiazepines, and opioids, leading to increased sedation and potentially dangerous respiratory depression.

See Also

• Sedative
• Insomnia
• Trichloroethanol
• Prodrug
• Electroencephalography